Association of genetic polymorphisms of IL1β -511 C>T, IL1RN VNTR 86 bp, IL6 -174 G>C, IL10 -819 C>T and TNFα -308 G>A, involved in symptomatic patients with dengue in Brazil.

Autor: Cansanção IF; Medicine Collegiate, Federal University of San Francisco Valley, Paulo Afonso, Bahia, Brazil. isaac.farias@univasf.edu.br.; Centro de Treinamento Profissional de Paulo Afonso (CFPPA), Rua Aurora, Bloco 27, Lote 3, Bairro Alves de Souza, Paulo Afonso, Brazil. isaac.farias@univasf.edu.br., do Carmo AP; Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil., Leite RD; São José Hospital of Infectious Diseases, Fortaleza, Ceará, Brazil.; Rua Nestor Barbosa, 315, Bairro Parquelândia, Fortaleza, Brazil., Portela RD; Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil., de Sá Leitão Paiva Júnior S; Genetics Department, Laboratory of Bioinformatics and Evolutionary Biology, Federal University of Pernambuco, Recife, Pernambuco, Brazil., de Queiroz Balbino V; Genetics Department, Laboratory of Bioinformatics and Evolutionary Biology, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Rabenhorst SH; Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2016 Nov; Vol. 65 (11), pp. 925-932. Date of Electronic Publication: 2016 Jul 19.
DOI: 10.1007/s00011-016-0975-5
Abstrakt: Objective: In this study, single nucleotide polymorphisms (SNP) of interleukin (IL) 1β -511C>T, IL1RN VNTR 86 bp, IL6 -174G>C, IL10 -819C>T and TNFα -308G>A were analyzed by PCR-RFLP with symptoms of dengue with the clinical features.
Subjects: 196 individuals admitted to the São José Infectious Diseases Hospital with suspected dengue infection. Dengue was confirmed in 111 of the patients. The control group consisted of 85 other individuals confirmed without dengue.
Results: It was demonstrated that the presence the T allele of IL1β (P < 0.05) was associated with susceptibility to developing the disease. Other results also suggested that the polymorphism in the combinations IL6 × IL1β (C and T alleles, respectively), IL1β (T allele) × IL1RN (*2/*2 genotype), IL6 (C allele) × TNFα (A allele), IL10 (C/T genotype) × TNFα (A/A genotype) (P < 0.01, P = 0.01, P < 0.05 and P = 0.03, respectively) were associated with predisposition to developing the disease and its symptoms.
Conclusions: In summary, the findings of this study in a Brazilian population point out the importance of studies of combinations of polymorphisms in the development of dengue, which can increase the risk of dengue infection and its severity.
Databáze: MEDLINE
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