Antinociceptive and antidepressant-like effects of the crude extract of Vitex megapotamica in rats.

Autor: Hamann FR; Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Zago AM; Pharmacy Undergraduation Program, Centro Universitário Franciscano - UNIFRA, Santa Maria, RS, Brazil., Rossato MF; Center of Innovation and Pre-clinical Pharmacology - CIEnP, Florianopolis, SC, Brazil., Beck VR; Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Mello CF; Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., de Brum TF; Graduate Program in Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., de Carvalho LM; Graduate Program in Chemistry, Center of Exact and Natural Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Faccin H; Graduate Program in Chemistry, Center of Exact and Natural Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil., Oliveira SM; Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: saramarchesan@hotmail.com., Rubin MA; Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: maribel.rubin@gmail.com.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2016 Nov 04; Vol. 192, pp. 210-216. Date of Electronic Publication: 2016 Jul 17.
DOI: 10.1016/j.jep.2016.07.045
Abstrakt: Ethnopharmacological Relevance: Vitex megapotamica (Spreng) Moldenke has been used in South American folk medicine to treat inflammatory diseases. However, the effects of V. megapotamica on animal models of nociception and depression have not been evaluated.
Aim of the Study: This study investigated whether the crude leaf extract of V. megapotamica exhibits antinociceptive and antidepressant-like effects in a Freund's adjuvant-induced chronic inflammation and depression model.
Materials and Methods: Chronic inflammation was induced in rats by the intraplantar administration of complete Freund's adjuvant (CFA; 100μl). The effect of oral crude extract of V. megapotamica (VmE; 3-30mg/kg, p.o.) on nociception (thermal hyperalgesia, mechanical allodynia and arthritis score), inflammation (edema, myeloperoxidase activity), immobility (forced swimming test), locomotor activity (open field), gastrointestinal transit, hyperalgesia and naloxone-precipitated morphine withdrawal syndrome was evaluated. Naloxone (0.4mg/kg, i.p.) was used to investigate the involvement of opioid system in the currently described effects of VmE.
Results: Crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model, which was prevented by naloxone. The VmE extract (10mg/kg, p.o.) did not alter the locomotor activity, gastrointestinal function and inflammatory parameters and did not cause hyperalgesia.
Conclusion: V. megapotamica induces opioid-dependent antinociception and antidepressant-like effect, without anti-inflammatory activity. The results support the use of VmE as analgesic and antidepressant.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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