The Prognostic Impact of Molecular Subtypes and Very Young Age on Breast Conserving Surgery in Early Stage Breast Cancer.

Autor:	Ordu C; Medical Oncology, Gayrettepe Florence Nightingale Hospital., McGuire K; General Surgery, University of North Carolina at Chapel Hill., Alco G; Radiation Oncology, Gayrettepe Florence Nightingale Hospital., Nur Pilanci K; Medical Oncology, Istanbul Bilim University., Koksal UI; Medical Oncology, Istanbul Bilim University., Elbüken F; Radiology, Gayrettepe Florence Nightingale Hospital., Erdogan Z; Physical Therapy and Rehabilitation, Istanbul Bilim University., Agacayak F; Radiology, Istanbul Florence Nightingale Hospital., Ilgun S; General Surgery, Istanbul Florence Nightingale Hospital., Sarsenov D; General Surgery, Istanbul Florence Nightingale Hospital., Öztürk A; General Surgery, Istanbul Florence Nightingale Hospital., İğdem Ş; Radiation Oncology, Gayrettepe Florence Nightingale Hospital., Okkan S; Radiation Oncology, Gayrettepe Florence Nightingale Hospital., Eralp Y; Medical Oncology, Istanbul University/Oncology Institute., Dincer M; Radiation Oncology, Gayrettepe Florence Nightingale Hospital., Ozmen V; Department of Surgery, Istanbul University.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2016 Jun 07; Vol. 8 (6), pp. e633. Date of Electronic Publication: 2016 Jun 07.
DOI:	10.7759/cureus.633
Abstrakt:	Background: Premenopausal breast cancer with a triple-negative phenotype (TNBC) has been associated with inferior locoregional recurrence free survival (LRFS) and overall survival (OS) after breast conserving surgery (BCS). The aim of this study is to analyze the association between age, subtype, and surgical treatment on survival in young women (≤40 years) with early breast cancer in a population with a high rate of breast cancer in young women. Methods: Three hundred thirty-two patients ≤40 years old with stage I-II invasive breast cancer who underwent surgery at a single institution between 1998 and 2012 were identified retrospectively. Uni- and multivariate analysis evaluated predictors of LRFS, OS, and disease free survival (DFS). Results: Most patients (64.2%) underwent BCS. Mean age and follow-up time were 35 (25 ± 3.61) years, and 72 months (range, 24-252), respectively. In multivariate analysis, multicentricity/multifocality and young age (<35 years) independently predicted for poorer DFS and OS. Those aged 35-40 years had higher LRFS and DFS than those <35 in the mastectomy group (p=0.007 and p=0.039, respectively). Patients with TNBC had lower OS compared with patients with luminal A subtype (p=0.042), and those who underwent BCS had higher OS than patients after mastectomy (p=0.015). Conclusion: Young age (< 35 years) is an independent predictor of poorer OS and DFS as compared with ages 35-40, even in countries with a lower average age of breast cancer presentation. In addition, TNBC in the young predicts for poorer OS. BCS can be performed in young patients with TNBC, despite their poorer overall survival.
Databáze:	MEDLINE
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