Effects of an ethanol extract and the diterpene, xylopic acid, of Xylopia aethiopica fruits in murine models of musculoskeletal pain.

Autor: Woode E; a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana., Ameyaw EO; b Department of Biomedical and Forensic Sciences, School of Biological Science , University of Cape Coast , Cape Coast , Ghana., Boakye-Gyasi E; a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana., Abotsi WK; a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana., Oppong Kyekyeku J; c Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana., Adosraku R; c Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana., Biney RP; a Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science & Technology , Kumasi , Ghana.
Jazyk: angličtina
Zdroj: Pharmaceutical biology [Pharm Biol] 2016 Dec; Vol. 54 (12), pp. 2978-2986. Date of Electronic Publication: 2016 Jul 18.
DOI: 10.1080/13880209.2016.1199040
Abstrakt: Context: Fruits of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) are used traditionally to manage arthritis, headache and other pain disorders.
Objective: The analgesic properties of the X. aethiopica ethanol fruit extract (XAE) and xylopic acid (XA) were evaluated in musculoskeletal pain models.
Materials and Methods: Acute muscle pain was induced in gastrocnemius muscle of Sprague-Dawley rats with 3% carrageenan (i.m.). Rats received XAE (30-300 mg/kg), XA (10-100 mg/kg) or morphine (1-10 mg/kg) after 12 h. Effects of XAE and XA on muscle pain were assessed by measuring post-treatment grip strength of the rats. Chronic muscle pain was similarly induced, but drug treatment was on the eighth day and effects of XAE and XA assessed with Randall-Selitto test for hyperlagesia. Acute-skeletal pain was induced in knee joints of rats with 3% carrageenan-kaolin mixture and effects determined 12-h later. Similar induction protocol was used for chronic knee pain with treatment and measurement as done for chronic muscle pain.
Results: XAE and XA significantly and dose-dependently ameliorated both acute muscle (ED 50 mg/kg: XAE = 22.9; XA = 6.2) and skeletal hyperalgesia (XAE = 39.9; XA = 17.7) induced by 3% carrageenan. Similarly, chronic skeletal hyperalgesia was reduced by XAE and XA treatment similar to morphine (ED 50 : XAE = 13.0; XA = 4.6). This reduction was also seen in chronic muscle hyperalgesia (ED 50 : XAE = 79.1; XA = 42.7). XAE and XA significantly reduced the spread of hyperalgesia to contralateral limbs in both models of chronic hyperalgesia.
Conclusion: These findings establish analgesic properties of the ethanol fruit extract of X. aethiopica and xylopic acid in musculoskeletal pain.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje