Clinical Regression and Remission of Primary Refractory Angiocentric Lymphoma Following Autologous Tumour Peptide Antigen-charged Dendritic Cells After High-dose Chemotherapy and Autologous Stem Cell Rescue.

Autor:	Taussig D; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., Williams MA; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., Wiggins C; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., Feakins RM; b Histopathology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., McBride N; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., Newland AC; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD., Kelsey SM; a Department of Haematology , St. Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London , Whitechapel, London E1 2AD.
Jazyk:	angličtina
Zdroj:	Hematology (Amsterdam, Netherlands) [Hematology] 1998; Vol. 3 (4), pp. 277-89.
DOI:	10.1080/10245332.1998.11746400
Abstrakt:	We report on the case of a 34-year old man with a previously refractory high-grade non-Hodgkin's Lymphoma which regressed following dendritic cell based immunotherapy after high-dose chemotherapy. Antigen presenting cells known as dendritic cells were cultured from harvested autologous peripheral blood progenitor cells. The dendritic cells were then exposed to unfractionated tumour peptides derived from a skin biopsy section inflitrated with lymphoma. These charged dendritic cells infused into the patient together with autologous T-lymphocytes after high-dose chemotherapy with peripheral blood stem cell rescue. Although the lymphoma relapsed after the high-dose chemotherapy it regressed again following the dendritic cell infusion. The patient's T-lymphocytes demonstrated in vitro reactivity to tumour peptides whereas the lymphocytes of controls did not. We propose that the lymphoma regression occurred because of a T cell mediated response against the tumour induced by the charged dendritic cells.
Databáze:	MEDLINE
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