Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study.

Autor:	Silventoinen K; Departments of Social Research and Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan; karri.silventoinen@helsinki.fi., Jelenkovic A; Departments of Social Research and Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain;, Sund R; Departments of Social Research and., Hur YM; Department of Education, Mokpo National University, Jeonnam, South Korea;, Yokoyama Y; Department of Public Health Nursing, Osaka City University, Osaka, Japan;, Honda C; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan;, Hjelmborg Jv; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and., Möller S; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and., Ooki S; Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan;, Aaltonen S; Departments of Social Research and Public Health, University of Helsinki, Helsinki, Finland;, Ji F; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;, Ning F; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;, Pang Z; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;, Rebato E; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain;, Busjahn A; HealthTwiSt GmbH, Berlin, Germany;, Kandler C; Department of Psychology, Bielefeld University, Bielefeld, Germany;, Saudino KJ; Department of Psychological and Brain Sciences, Boston University, Boston, MA;, Jang KL; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada;, Cozen W; Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CA;, Hwang AE; Department of Preventive Medicine, Keck School of Medicine of USC, and., Mack TM; Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CA;, Gao W; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;, Yu C; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;, Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;, Corley RP; Institute for Behavioral Genetics, Boulder, CO;, Huibregtse BM; Institute for Behavioral Genetics, Boulder, CO;, Christensen K; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and Departments of Clinical Biochemistry and Pharmacology Clinical Genetics., Skytthe A; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and., Kyvik KO; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Odense Patient data Explorative Network, and., Derom CA; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium;, Vlietinck RF; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium;, Loos RJ; The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY;, Heikkilä K; Public Health, University of Helsinki, Helsinki, Finland;, Wardle J; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;, Llewellyn CH; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;, Fisher A; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;, McAdams TA; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and., Eley TC; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and., Gregory AM; Department of Psychology, Goldsmiths, University of London, London, United Kingdom;, He M; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia;, Ding X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China;, Bjerregaard-Andersen M; Departments of Endocrinology and Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau; Research Center for Vitamins and Vaccines, Statens Serum Institute, Copenhagen, Denmark;, Beck-Nielsen H; Departments of Endocrinology and., Sodemann M; Departments of Endocrinology and Infectious Diseases, Odense University Hospital, Odense, Denmark;, Tarnoki AD; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, Hungary;, Tarnoki DL; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, Hungary;, Stazi MA; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;, Fagnani C; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;, D'Ippolito C; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;, Knafo-Noam A; The Hebrew University of Jerusalem, Jerusalem, Israel;, Mankuta D; Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel;, Abramson L; The Hebrew University of Jerusalem, Jerusalem, Israel;, Burt SA; Michigan State University, East Lansing, MI;, Klump KL; Michigan State University, East Lansing, MI;, Silberg JL; Department of Human and Molecular Genetics., Eaves LJ; Department of Human and Molecular Genetics., Maes HH; Department of Human and Molecular Genetics, Massey Cancer Center, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA;, Krueger RF; Department of Psychology, University of Minnesota, Minneapolis, MN;, McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN;, Pahlen S; Department of Psychology, University of Minnesota, Minneapolis, MN;, Gatz M; Department of Psychology, University of Southern California, Los Angeles, CA; Departments of Medical Epidemiology and Biostatistics and., Butler DA; Institute of Medicine, National Academy of Sciences Washington, DC;, Bartels M; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;, van Beijsterveldt TC; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;, Craig JM; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;, Saffery R; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;, Freitas DL; Department of Physical Education and Sport, University of Madeira, Funchal, Portugal;, Maia JA; Centre of Research, Education, Innovation and Intervention in Sport, Faculty of Sport, Porto, University of Porto, Portugal;, Dubois L; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada;, Boivin M; École de psychologie, Université Laval, Québec, Canada; Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian Federation;, Brendgen M; Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada;, Dionne G; École de psychologie, Université Laval, Québec, Canada;, Vitaro F; École de psychoéducation, Université de Montréal, Montréal, Québec, Canada;, Martin NG; Genetic Epidemiology Department and., Medland SE; Genetic Epidemiology Department and., Montgomery GW; Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia;, Chong Y; Department of Psychology, Pusan National University, Busan, South Korea;, Swan GE; Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA;, Krasnow R; Center for Health Sciences, SRI International, Menlo Park, CA;, Magnusson PK; Departments of Medical Epidemiology and Biostatistics and., Pedersen NL; Departments of Medical Epidemiology and Biostatistics and., Tynelius P; Public Health Sciences, Karolinska Institutet, Stockholm, Sweden;, Lichtenstein P; Departments of Medical Epidemiology and Biostatistics and., Haworth CM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;, Plomin R; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and., Bayasgalan G; Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia;, Narandalai D; Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;, Harden KP; Department of Psychology, University of Texas at Austin, Austin, TX;, Tucker-Drob EM; Department of Psychology, University of Texas at Austin, Austin, TX;, Öncel SY; Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey;, Aliev F; Department of Human and Molecular Genetics, Departments of Psychiatry and Psychology., Spector T; Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;, Mangino M; Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;, Lachance G; Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;, Baker LA; Department of Psychology, University of Southern California, Los Angeles, CA;, Tuvblad C; Department of Psychology, University of Southern California, Los Angeles, CA; Örebro University, School of Law, Psychology and Social Work, Örebro, Sweden;, Duncan GE; College of Medicine, Washington State University - Health Sciences Spokane, Spokane, WA;, Buchwald D; Washington State Twin Registry, Washington State University, Seattle, WA;, Willemsen G; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;, Rasmussen F; Public Health Sciences, Karolinska Institutet, Stockholm, Sweden;, Goldberg JH; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA;, Sørensen TIa; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Novo Nordisk Foundation Center for Basic Metabolic Research (Section on Metabolic Genetics) and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen,Denmark; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, The Capital Region, Denmark;, Boomsma DI; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;, Kaprio J; Public Health, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; and Institute for Molecular Medicine FIMM, Helsinki, Finland.
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2016 Aug; Vol. 104 (2), pp. 371-9. Date of Electronic Publication: 2016 Jul 13.
DOI:	10.3945/ajcn.116.130252
Abstrakt:	Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity. (© 2016 American Society for Nutrition.)
Databáze:	MEDLINE
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