Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux.

Autor: Asseff IL; Interdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico., Gaucin GB; Pediatrics and Neonatology Services, General Hospital of Durango, Durango, Mexico., Olguín HJ; Laboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico. juarezol@yahoo.com., Nájera JA; Interdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico., López AT; Laboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico., Guillé GP; Laboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico., Torres FZ; Interdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2016 Jul 13; Vol. 16, pp. 90. Date of Electronic Publication: 2016 Jul 13.
DOI: 10.1186/s12887-016-0630-x
Abstrakt: Background: The aim of this study was to determine the effect of gestational age on pharmacokinetics of ranitidine in newborns with gastroesophageal reflux.
Methods: A prospective, descriptive and pharmacokinetic study was carried out in 30 pre-term and 20 full-term babies. 3 mg/kg of ranitidine was administered intravenously to all the babies and at 0.25, 0.5, 1, 2, 4, and 8 h following the administration, samples of blood were drawn to assess ranitidine levels using high performance liquid chromatographic technique.
Results: Pharmacokinetics of ranitidine had a bi-exponential behavior with a half-life elimination of (t1/2el) 2.79 h, area under curve (AUC) of 1688 ng/mL, volume of distribution (Vd) of 1.44 L/kg, and clearance (Cl) of 5.9 L/kg/h. The median plasmatic concentration in pre-terms was 1113 ng/mL and 280 ng/mL in full-terms. Vd, t1/2 and Cl presented high values in preterm although the correlation of Cl with glomerular filtration in term newborns was better.
Conclusions: Plasma levels of ranitidine depend on the gestational age of the newborns. However, the possible relationship between after-birth age and pharmacokinetics of the neonates as their internal organs get matured without minding their gestational background.
Databáze: MEDLINE
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