On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction.

Autor: Konieczynska MD; Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA., Villa-Camacho JC; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA., Ghobril C; Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA., Perez-Viloria M; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA., Tevis KM; Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA., Blessing WA; Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA., Nazarian A; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA., Rodriguez EK; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA., Grinstaff MW; Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA. mgrin@bu.edu.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Aug 16; Vol. 55 (34), pp. 9984-7. Date of Electronic Publication: 2016 Jul 13.
DOI: 10.1002/anie.201604827
Abstrakt: An adhesive yet easily removable burn wound dressing represents a breakthrough in second-degree burn wound care. Current second-degree burn wound dressings absorb wound exudate, reduce bacterial infections, and maintain a moist environment for healing, but are surgically or mechanically debrided from the wound, causing additional trauma to the newly formed tissues. We have developed an on-demand dissolvable dendritic thioester hydrogel burn dressing for second-degree burn care. The hydrogel is composed of a lysine-based dendron and a PEG-based crosslinker, which are synthesized in high yields. The hydrogel burn dressing covers the wound and acts as a barrier to bacterial infection in an in vivo second-degree burn wound model. A unique feature of the hydrogel is its capability to be dissolved on-demand, via a thiol-thioester exchange reaction, allowing for a facile burn dressing removal.
(© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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