Granulocyte-Macrophage Colony-Stimulating Factor in Newly Diagnosed Adult Patients with Acute Lymphoblastic Leukemia Treated with Conventional Chemotherapy.

Autor:	Harakati MS; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Al-Momen A; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Ajarim DS; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Al-Mohareb FI; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Diab AA; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Aleem A; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Fawzy EM; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Al-Anazi AR; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia., Al-Gwaiz L; a From the Department of Medicine (Division of Hematology/Oncology & Division of Infectious Diseases).; b From the Department of Pathology (Section of Hematopathology) , College of Medicine & King Khalid University Hospital , Riyadh , Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Hematology (Amsterdam, Netherlands) [Hematology] 1996; Vol. 1 (3), pp. 207-14.
DOI:	10.1080/10245332.1996.11746306
Abstrakt:	Twenty consecutive adult patients with newly diagnosed acute lymphoblastic leukemia (ALL) were treated with conventional therapy consisting of daunorubicin, vincristine, prednisone and L-asparaginase in standard doses. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was administered at a single subcutaneous daily dose of 5 microgram per kilogram body weight for fourteen days starting on day 7 of chemotherapy. Twenty two adult patients with acute lymphoblastic leukemia and similar risk characteristics who received the same chemotherapeutic regimen without GM-CSF served as a historical control group. The complete remission rate and the rate of early mortality were similar in both groups of patients. Patients treated with GM-CSF showed significantly faster neutrophil recovery above 0.5 × 10(9)/L than the control patients (P < 0.005). The incidence of febrile episodes and the rate of documented infection were similar in the two groups of patients.
Databáze:	MEDLINE
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