Proteomics approaches in cervical cancer: focus on the discovery of biomarkers for diagnosis and drug treatment monitoring.

Autor:	Kontostathi G; a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.; b Laboratory of Biology , University of Athens School of Medicine , Athens , Greece., Zoidakis J; a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece., Anagnou NP; b Laboratory of Biology , University of Athens School of Medicine , Athens , Greece.; c Cell and Gene Therapy Laboratory , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece., Pappa KI; c Cell and Gene Therapy Laboratory , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.; d First Department of Obstetrics and Gynecology , University of Athens School of Medicine , Athens , Greece., Vlahou A; a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece., Makridakis M; a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.
Jazyk:	angličtina
Zdroj:	Expert review of proteomics [Expert Rev Proteomics] 2016 Aug; Vol. 13 (8), pp. 731-45.
DOI:	10.1080/14789450.2016.1210514
Abstrakt:	Introduction: The HPV virus accounts for the majority of cervical cancer cases. Although a diagnostic tool (Pap Test) is widely available, cervical cancer incidence still remains high worldwide, and especially in developing countries, attributed to a large extent to suboptimal sensitivities of the Pap test and unavailability of the test in developing countries. Areas Covered: Proteomics approaches have been used in order to understand the HPV virus correlation to cervical cancer pathology, as well as to discover putative biomarkers for early cervical cancer diagnosis and drug mode of action. Expert commentary: The present review summarizes the latest in vitro and in vivo proteomic studies for the discovery of putative cervical cancer biomarkers and the evaluation of available drugs and treatments.
Databáze:	MEDLINE
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