Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.

Autor: Bi W; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China. Electronic address: biwei@hb2h.com., Bi Y; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Gao X; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA., Yan X; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA., Zhang Y; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Harris J; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA., Legalley TD; Marquette General Heart and Vascular Institute, Marquette General Hospital, Marquette, MI 49855, USA., Gibson KM; Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA 99202, USA. Electronic address: mike.gibson@wsu.edu., Bi L; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA. Electronic address: lanrong@mtu.edu.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 15; Vol. 26 (16), pp. 4042-51. Date of Electronic Publication: 2016 Jun 28.
DOI: 10.1016/j.bmcl.2016.06.079
Abstrakt: We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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