Applying theoretical premises of binary toxicity mathematical modeling to combined impacts of chemical plus physical agents (A case study of moderate subchronic exposures to fluoride and static magnetic field).

Autor: Katsnelson BA; Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia. Electronic address: bkaznelson@etel.ru., Tsepilov NA; Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia., Panov VG; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia., Sutunkova MP; Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia., Varaksin AN; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia., Gurvich VB; Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia., Minigalieva IA; Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia., Valamina IE; Ural State Medical University, Ekaterinburg, Russia., Makeyev OH; Ural State Medical University, Ekaterinburg, Russia., Meshtcheryakova EY; Ural State Medical University, Ekaterinburg, Russia.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2016 Sep; Vol. 95, pp. 110-20. Date of Electronic Publication: 2016 Jul 04.
DOI: 10.1016/j.fct.2016.06.024
Abstrakt: Sodium fluoride solution was injected i.p. to rats at a dose equivalent to 0.1 LD50 three times a week up to 18 injections. Two thirds of these rats and of the sham-injected ones were exposed to the whole body impact of a 25 mT static magnetic field for 2 or 4 h a day, 5 times a week. For mathematical analysis of the effects they produced in combination, we used a response surface model. This analysis demonstrated that (like in combined toxicity) the combined adverse action of a chemical plus a physical agent was characterized by a diversity of types depending not only on particular effects these types were assessed for but on their level as well. From this point of view, the indices for which at least one statistically significant effect was observed could be classified as identifying (1) single-factor action; (2) additivity; (3) synergism; (4) antagonism (both subadditive unidirectional action and all variants of contradirectional action). Although the classes (2) and (3) taken together encompass a smaller part of the indices, the biological importance of some of them renders the combination of agents studied as posing a higher health risk than that associated with each them acting alone.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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