Planning-free cerebral blood flow territory mapping in patients with intracranial arterial stenosis.

Autor:	Arteaga DF; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Strother MK; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Davis LT; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Fusco MR; 2 Neurosurgery, Vanderbilt University Medical Center, Nashville, USA., Faraco CC; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Roach BA; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Scott AO; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA., Donahue MJ; 1 Radiology, Vanderbilt University Medical Center, Nashville, USA.; 3 Psychiatry, Vanderbilt University Medical Center, Nashville, USA.; 4 Physics and Astronomy, Vanderbilt University, Nashville, USA.; 5 Neurology, Vanderbilt University Medical Center, Nashville, USA.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Jun; Vol. 37 (6), pp. 1944-1958. Date of Electronic Publication: 2016 Jan 01.
DOI:	10.1177/0271678X16657573
Abstrakt:	A noninvasive method for quantifying cerebral blood flow and simultaneously visualizing cerebral blood flow territories is vessel-encoded pseudocontinuous arterial spin labeling MRI. However, obstacles to acquiring such information include limited access to the methodology in clinical centers and limited work on how clinically acquired vessel-encoded pseudocontinuous arterial spin labeling data correlate with gold-standard methods. The purpose of this work is to develop and validate a semiautomated pipeline for the online quantification of cerebral blood flow maps and cerebral blood flow territories from planning-free vessel-encoded pseudocontinuous arterial spin labeling MRI with gold-standard digital subtraction angiography. Healthy controls (n = 10) and intracranial atherosclerotic disease patients (n = 34) underwent 3.0 T MRI imaging including vascular (MR angiography) and hemodynamic (cerebral blood flow-weighted arterial spin labeling) MRI. Patients additionally underwent catheter and/or CT angiography. Variations in cross-territorial filling were grouped according to diameters of circle of Willis vessels in controls. In patients, Cohen's k-statistics were computed to quantify agreement in perfusion patterns between vessel-encoded pseudocontinuous arterial spin labeling and angiography. Cross-territorial filling patterns were consistent with circle of Willis anatomy. The intraobserver Cohen's k-statistics for cerebral blood flow territory and digital subtraction angiography perfusion agreement were 0.730 (95% CI = 0.593-0.867; reader one) and 0.708 (95% CI = 0.561-0.855; reader two). These results support the feasibility of a semiautomated pipeline for evaluating major neurovascular cerebral blood flow territories in patients with intracranial atherosclerotic disease.
Databáze:	MEDLINE
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