Schizotypy and auditory mismatch negativity in a non-clinical sample of young adults.

Autor: Broyd SJ; School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia. Electronic address: sbroyd@uow.edu.au., Michie PT; School of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health University of Newcastle, Newcastle, NSW, Australia., Bruggemann J; School of Psychiatry, University of New South Wales and Neuroscience Research Australia, Sydney, Australia., van Hell HH; School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia., Greenwood LM; School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia., Croft RJ; School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia., Todd J; School of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health University of Newcastle, Newcastle, NSW, Australia., Lenroot R; School of Psychiatry, University of New South Wales and Neuroscience Research Australia, Sydney, Australia., Solowij N; School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2016 Aug 30; Vol. 254, pp. 83-91. Date of Electronic Publication: 2016 Jun 21.
DOI: 10.1016/j.pscychresns.2016.06.011
Abstrakt: Schizophrenia may be conceptualised using a dimensional approach to examine trait-like expression such as schizotypy within non-clinical populations to better understand pathophysiology. A candidate psychosis-risk marker, the auditory mismatch negativity (MMN) is thought to index the functionality of glutamatergic NMDA receptor mediated neurotransmission. Although the MMN is robustly reduced in patients with schizophrenia, the association between MMN and schizotypy in the general population is under-investigated. Thirty-five healthy participants completed the Schizotypal Personality Questionnaire (SPQ) and a multi-feature MMN paradigm (standards 82%, 50ms, 1000Hz, 80dB) with duration (100ms), frequency (1200Hz) and intensity (90dB) deviants (6% each). Spearman's correlations were used to explore the association between schizotypal personality traits and MMN amplitude. Few associations were identified between schizotypal traits and MMN. Higher Suspiciousness subscale scores tended to be correlated with larger frequency MMN amplitude. A median-split comparison of the sample on Suspiciousness scores showed larger MMN (irrespective of deviant condition) in the High compared to the Low Suspiciousness group. The trend-level association between MMN and Suspiciousness is in contrast to the robustly attenuated MMN amplitude observed in schizophrenia. Reductions in MMN may reflect a schizophrenia-disease state, whereas non-clinical schizotypy may not be subserved by similar neuropathology.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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