Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina.

Autor:	Barboni MT; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil., Martins CM; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil., Nagy BV; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil., Tsai T; Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany., Damico FM; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil 4Departamento de Oftalmologia, Faculdade de Medicina, Uni., da Costa MF; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil., de Cassia R, Pavanello M; Centro de Pesquisas do Genoma Humano e Células-Tronco Universidade de São Paulo, São Paulo, Brasil., Lourenço NC; Centro de Pesquisas do Genoma Humano e Células-Tronco Universidade de São Paulo, São Paulo, Brasil., de Cerqueira AM; Centro de Pesquisas do Genoma Humano e Células-Tronco Universidade de São Paulo, São Paulo, Brasil., Zatz M; Centro de Pesquisas do Genoma Humano e Células-Tronco Universidade de São Paulo, São Paulo, Brasil., Kremers J; Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany., Ventura DF; Núcleo de Neurociências e Comportamento, Universidade de São Paulo, São Paulo, Brasil 2Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, Brasil.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2016 Jul 01; Vol. 57 (8), pp. 3581-7.
DOI:	10.1167/iovs.16-19287
Abstrakt:	Purpose: Visual information is processed in parallel pathways in the visual system. Parallel processing begins at the synapse between the photoreceptors and their postreceptoral neurons in the human retina. The integrity of this first neural connection is vital for normal visual processing downstream. Of the numerous elements necessary for proper functioning of this synaptic contact, dystrophin proteins in the eye play an important role. Deficiency of muscle dystrophin causes Duchenne muscular dystrophy (DMD), an X-linked disease that affects muscle function and leads to decreased life expectancy. In DMD patients, postreceptoral retinal mechanisms underlying scotopic and photopic vision and ON- and OFF-pathway responses are also altered. Methods: In this study, we recorded the electroretinogram (ERG) while preferentially activating the (red-green) opponent or the luminance pathway, and compared data from healthy participants (n = 16) with those of DMD patients (n = 10). The stimuli were heterochromatic sinusoidal modulations at a mean luminance of 200 cd/m2. The recordings allowed us also to analyze ON and OFF cone-driven retinal responses. Results: We found significant differences in 12-Hz response amplitudes and phases between controls and DMD patients, with conditions with large luminance content resulting in larger response amplitudes in DMD patients compared to controls, whereas responses of DMD patients were smaller when pure chromatic modulation was given. Conclusions: The results suggest that dystrophin is required for the proper function of luminance and red-green cone opponent mechanisms in the human retina.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu