Experimental and molecular docking investigation on DNA interaction of N-substituted phthalimides: antibacterial, antioxidant and hemolytic activities.
Autor: | Nayab PS; Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, Delhi, India., Irfan M; Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, Delhi, India., Abid M; Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, Delhi, India., Pulaganti M; Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram, 515003, Andhra Pradesh, India., Nagaraju C; Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram, 515003, Andhra Pradesh, India., Chitta SK; Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram, 515003, Andhra Pradesh, India., Rahisuddin; Department of Chemistry, Jamia Millia Islamia, New Delhi, 110025, Delhi, India. |
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Jazyk: | angličtina |
Zdroj: | Luminescence : the journal of biological and chemical luminescence [Luminescence] 2017 May; Vol. 32 (3), pp. 298-308. Date of Electronic Publication: 2016 Jul 06. |
DOI: | 10.1002/bio.3178 |
Abstrakt: | A series of Schiff base molecules derived from a phthalimide scaffold was investigated as efficient antibacterial, antioxidant and DNA-interacting agents. The spectroscopic characterization of these derivatives was studied in detail using elemental analysis and spectroscopic techniques. The DNA-binding profile of title molecules against Ct-DNA (calf thymus) was investigated by absorbance, fluorescence, hydrodynamics and thermal denaturation investigations. The bacterial inhibition potential of these molecules was investigated against Escherichia coli and Staphylococcus aureus. Molecule 3c emerged as the most active against S. aureus (IC (Copyright © 2016 John Wiley & Sons, Ltd.) |
Databáze: | MEDLINE |
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