Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects.

Autor: Zhavbert ES; Materia Medica Holding, Moscow, Russia. zhavbertes@materiamedica.ru., Surkova EI; Materia Medica Holding, Moscow, Russia., Yakovleva NN; Materia Medica Holding, Moscow, Russia., Dugina YL; Materia Medica Holding, Moscow, Russia., Epshtein OI; Materia Medica Holding, Moscow, Russia., Bugaeva LI; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia., Lebedeva SA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia., Petrov VI; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Jun; Vol. 161 (2), pp. 252-6. Date of Electronic Publication: 2016 Jul 07.
DOI: 10.1007/s10517-016-3389-z
Abstrakt: We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity.
Databáze: MEDLINE
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