| Autor: |
de Brito BS; Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Gaspar NG; Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Egal ES; Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Sanchez-Romero C; Oral Pathology Department, Piracicaba Dental School, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Martins AS; Head and Neck Surgery Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Tincani ÁJ; Head and Neck Surgery Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., de Oliveira Gondak R; Pathology Department, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil., de Almeida OP; Oral Pathology Department, Piracicaba Dental School, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Kowalski LP; Head and Neck Surgery Department, AC Camargo Cancer Center, São Paulo, SP, Brazil., Altemani A; Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Mariano FV; Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil. fevimariano@gmail.com.; Departamento de Anatomia Patológica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Av. Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, SP, 13083-887, Brazil. fevimariano@gmail.com. |
| Abstrakt: |
The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and >50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA. |
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