The effect of parental 5,10-methylenetetrahydrofolate reductase 677C/T and 1298A/C gene polymorphisms on response to single-dose methotrexate in tubal ectopic pregnancy.

Autor: Kutuk MS; a Department of Obstetrics and Gynecology , Erciyes University , Kayseri , Turkey and., Subasioglu A; b Department of Medical Genetics , Faculty of Medicine, Erciyes University , Kayseri , Turkey., Uludag S; a Department of Obstetrics and Gynecology , Erciyes University , Kayseri , Turkey and., Tascioglu N; b Department of Medical Genetics , Faculty of Medicine, Erciyes University , Kayseri , Turkey., Ozgun MT; a Department of Obstetrics and Gynecology , Erciyes University , Kayseri , Turkey and., Dundar M; b Department of Medical Genetics , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
Jazyk: angličtina
Zdroj: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2017 May; Vol. 30 (10), pp. 1232-1237. Date of Electronic Publication: 2016 Aug 02.
DOI: 10.1080/14767058.2016.1209652
Abstrakt: Object: The aim of this study was to assess the effect of parental 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (677C/T and 1298A/C) on response to single-dose methotrexate (MTX) treatment in tubal ectopic pregnancy (TEP).
Materials and Methods: In this prospective cohort study, cases with unruptured TEPs were grouped into two according to their response to single-dose MTX treatment (Group 1: responsive, n:88; Group 2: unresponsive, n:21). The groups were compared with regard to baseline demographic and clinical parameters. As a main outcome measure, the independent effects of parental MTHFR gene polymorphisms on response to single dose MTX treatment were evaluated.
Results: One hundred and nine unruptured TEP were included in the final analysis. The mean maternal age was 29.30 ± 5.21 years, gravity 2 (min-max: 1-5), parity 1 (min-max: 0-4). The median serum beta-human chorionic gonadotropin (β-hCG) was 1403.35 MI/I (Q 1 -Q 3 : 517-2564). The overall response rate was 81% (88/109). The groups were similar with respect to basic baseline demographic data and serum β-hCG level. Binary logistic regression analysis showed that the presence of parental MTHFR677C/T and 1298A/C polymorphism were not independent factor predicting treatment success (p > 0.05). The only independent factor for resistance to single dose MTX was the previous TEP (OR: 4.47 (1.18-16.9)).
Conclusion: Parental MTHFR 677C/T and 1298A/C mutations do not predict the outcome of single dose intramuscular MTX treatment in unruptured TEP.
Databáze: MEDLINE
Externí odkaz: