Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma.

Autor:	Salcedo-Hernandez RA; Department of Surgical Oncology, National Institute for Cancer Research, Mexico City, Mexico., Lino-Silva LS; Department of Anatomic Pathology, National Institute for Cancer Research, Mexico City, Mexico - Saul.lino.sil@gmail.com., Isla-Ortiz D; Department of Surgical Oncology, National Institute for Cancer Research, Mexico City, Mexico., Posada-Torres JA; Department of Surgical Oncology, National Institute for Cancer Research, Mexico City, Mexico., Chanona-Vilchis JG; Department of Anatomic Pathology, National Institute for Cancer Research, Mexico City, Mexico., Perez-Montiel MD; Department of Anatomic Pathology, National Institute for Cancer Research, Mexico City, Mexico., Aguilar-Romero JM; School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Dominguez-Rodriguez JA; School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico., Herrera-Gomez A; Department of Surgical Oncology, National Institute for Cancer Research, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia [G Ital Dermatol Venereol] 2017 Feb; Vol. 152 (1), pp. 8-12. Date of Electronic Publication: 2016 Jul 05.
DOI:	10.23736/S0392-0488.16.05192-0
Abstrakt:	Background: Melanoma of the vulva is the second most common vulvar cancer after epidermoid carcinoma. Patients suffering from this disease usually present with a late-stage disease with a poor prognosis. The prognostic factors reported in previous studies are not homogeneous and the clinical/pathogenic role of c-KIT expression is not clear. Breslow staging currently is the most accurate predictor factor. Methods: A clinicopathological study with literature review was performed to identify predictors of prognosis and survival in melanoma of the vulva and investigated the expression of c-KIT (by immunohistochemistry) in 10 patients from the National Institute for Cancer Research (Mexico City). Results: The 10 patients enrolled were all older women with delayed presentation, high-stage disease and limited response to treatment. Five patients (50%) were found to have c-KIT expression; 4 of them recurred (P=0.01), and ultimately 3 died (P=0.038). We identified satellitosis and c-KIT expression as prognostic predictors for death. Conclusions: We conclude that c-KIT expression is a valuable predictor of prognosis and survival, especially in thick (>4 mm) melanomas.
Databáze:	MEDLINE
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