Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System.

Autor:	Bains RS; Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK., Cater HL; Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK., Sillito RR; Actual Analytics Ltd Edinburgh, UK., Chartsias A; Actual Analytics Ltd Edinburgh, UK., Sneddon D; Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK., Concas D; Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK., Keskivali-Bond P; Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK., Lukins TC; Actual Analytics Ltd Edinburgh, UK., Wells S; Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK., Acevedo Arozena A; Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK., Nolan PM; Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK., Armstrong JD; Actual Analytics LtdEdinburgh, UK; School of Informatics, University of EdinburghEdinburgh, UK.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2016 Jun 10; Vol. 10, pp. 106. Date of Electronic Publication: 2016 Jun 10 (Print Publication: 2016).
DOI:	10.3389/fnbeh.2016.00106
Abstrakt:	Central nervous system disorders such as autism as well as the range of neurodegenerative diseases such as Huntington's disease are commonly investigated using genetically altered mouse models. The current system for characterizing these mice usually involves removing the animals from their home-cage environment and placing them into novel environments where they undergo a battery of tests measuring a range of behavioral and physical phenotypes. These tests are often only conducted for short periods of times in social isolation. However, human manifestations of such disorders are often characterized by multiple phenotypes, presented over long periods of time and leading to significant social impacts. Here, we have developed a system which will allow the automated monitoring of individual mice housed socially in the cage they are reared and housed in, within established social groups and over long periods of time. We demonstrate that the system accurately reports individual locomotor behavior within the group and that the measurements taken can provide unique insights into the effects of genetic background on individual and group behavior not previously recognized.
Databáze:	MEDLINE
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