Cancer in Parkinson's disease.

Autor: Tacik P; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: tacik.pawel@mayo.edu., Curry S; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: sadie.e.curry@gmail.com., Fujioka S; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA; Department of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, Japan. Electronic address: shinsuke@cis.fukuoka-u.ac.jp., Strongosky A; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: strongosky.audrey@mayo.edu., Uitti RJ; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: uitti@mayo.edu., van Gerpen JA; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: vangerpen.jay@mayo.edu., Diehl NN; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: diehl.nancy@mayo.edu., Heckman MG; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: heckman.michael@mayo.edu., Wszolek ZK; Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. Electronic address: Wszolek.Zbigniew@mayo.edu.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2016 Oct; Vol. 31, pp. 28-33. Date of Electronic Publication: 2016 Jun 20.
DOI: 10.1016/j.parkreldis.2016.06.014
Abstrakt: Introduction: We examined the prevalence of cancer in patients with Parkinson's disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014.
Methods: We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unrelated PD patients and 478 controls, and all were white. For PD patients, we examined cancers diagnosed before and after PD diagnosis separately in addition to considering all cancer diagnoses.
Results: Twenty different cancers were identified. In PD patients, the most common types of cancer were skin cancer (17.3% overall; 10.6% before PD), followed by nonmelanoma skin cancer (16.0% overall; 9.7% before PD), prostate cancer in men (12.8% overall; 9.2% before PD), breast cancer in women (10.6% overall; 6.3% before PD), and melanoma (2.4% overall; 1.1% before PD). Compared to controls, a significantly lower frequency of nonmelanoma skin cancer (odds ratio [OR]: 0.62, P = 0.0024) and any skin cancer (OR: 0.57, P = 0.0002) was observed in PD patients. These differences were greater when considering only cases with cancers that occurred before PD diagnosis (OR: 0.49, P < 0.0001; OR: 0.45, P < 0.0001, respectively), and there was a lower frequency of melanoma and any cancer preceding PD diagnosis compared to controls (OR: 0.31, P = 0.003; OR: 0.36, P < 0.0001). There was no evidence of a frequency difference for any other cancer.
Conclusions: PD patients had a lower frequency of skin cancers or any cancer prior to PD diagnosis compared to controls, suggesting that cancer may have a protective effect on PD risk.
Competing Interests: Financial Disclosure/Conflict of Interest: Pawel Tacik, MD: Jaye F. and Betty F. Dyer Foundation Fellowship, Max Kade Foundation postdoctoral fellowship, Allergan Medical Education grant Sadie Curry: nothing to disclose Shinsuke Fujioka, MD: gift from Carl Edward Bolch, Jr. and Susan Bass Bolch Foundation Audrey Strongosky, BS: NIH P50 NS072187 Ryan J. Uitti, MD: NINDS P50 NS072187 Jay A. van Gerpen, MD: NINDS P50 NS072187 Nancy N. Diehl, BS: nothing to disclose Michael G. Heckman, MS: nothing to disclose Zbigniew K. Wszolek, MD: NIH P50 NS072187, Mayo Clinic Neuroscience Focused Research Team and Cecilia and Dan Carmichael Family Foundation. There are no conflicts of interest.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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