Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine.

Autor: Mao ZW; School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China., Zheng X; Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China., Lin YP; School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China., Hu CY; School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China., Wang XL; School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China., Wan CP; Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China. Electronic address: wanchunping1012@163.com., Rao GX; School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China. Electronic address: rao13987124569@qq.com.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 01; Vol. 26 (15), pp. 3421-4. Date of Electronic Publication: 2016 Jun 21.
DOI: 10.1016/j.bmcl.2016.06.055
Abstrakt: A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been designed and prepared. These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines by MTT assay. The results demonstrated that amide derivatives were more bioactive than sulfonamide compounds in general, and that chloro or trifluoromethyl substituent was vital for modulating cytotoxic activity. In particular, compound 13 was found to be the most potent compound against 4 strains human tumor cell lines, and exhibited cytotoxic activity selectively against Hela (0.03μM).
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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