| Autor: |
Song Z, Huang Y, Prasad V, Baumgartner R, Zhang S, Harris K, Katz JS; Formulation Science, Corporate Research and Development, The Dow Chemical Company , Collegeville, Pennsylvania 19426, United States., Cheng J |
| Jazyk: |
angličtina |
| Zdroj: |
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2016 Jul 13; Vol. 8 (27), pp. 17033-7. Date of Electronic Publication: 2016 Jul 01. |
| DOI: |
10.1021/acsami.6b05847 |
| Abstrakt: |
Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows the polymerization-induced self-assembly into well-defined polymersomes with ultrathick membranes up to ∼47 nm. These ultrathick membranes significantly enhance the resistance against surfactant solubilization of the vesicles, improving the vesicles' potential for use in industrial encapsulations. Vesicle-encapsulated actives are well retained in the presence of up to 40 wt % of various anionic and nonionic surfactants, with less than 7% active leakage being observed after 30 days. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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