Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer.

Autor:	Knott ME; Instituto de Oncología 'Ángel H Roffo', Universidad de Buenos Aires (UBA), Argentina., Minatta JN; Hospital Italiano de Buenos Aires- Buenos Aires, Argentina., Roulet L; Hospital Italiano de Buenos Aires- Buenos Aires, Argentina., Gueglio G; Hospital Italiano de Buenos Aires- Buenos Aires, Argentina., Pasik L; Instituto de Oncología 'Ángel H Roffo', Universidad de Buenos Aires (UBA), Argentina., Ranuncolo SM; Instituto de Oncología 'Ángel H Roffo', Universidad de Buenos Aires (UBA), Argentina., Nuñez M; Facultad de Farmacia y Bioquímica UBA, Argentina., Puricelli L; Instituto de Oncología 'Ángel H Roffo', Universidad de Buenos Aires (UBA), Argentina., De Lorenzo MS; Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers, State University of New Jersey, USA.
Jazyk:	angličtina
Zdroj:	Journal of molecular biomarkers & diagnosis [J Mol Biomark Diagn] 2016 Jun; Vol. 1 (Suppl 2). Date of Electronic Publication: 2016 May 20.
DOI:	10.4172/2155-9929.S2-015
Abstrakt:	Background: The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response. In this study, we evaluated the role of circulating FGF21, an endocrine factor, as a diagnostic and prognostic biomarker for ccRCC. Materials and Methods: Serum samples from healthy controls (HC), clear cell and chromophobe RCC cancer patients were obtained from the serum biobank "Biobanco Público de Muestras Séricas Oncológicas" (BPMSO) of the "Instituto de Oncología "Ángel H. Roffo". Serum FGF21 and leptin were measured by ELISA while other metabolic markers were measured following routinely clinical procedures. Results: One of our major findings was that FGF21 levels were significantly increased in ccRCC patients compared with HC. Moreover, we showed an association between the increased serum FGF21 levels and the shorter disease free survival in a cohort of 98 ccRCC patients, after adjustment for other predictors of outcome. Conclusion: Our results suggest that higher FGF21 serum level is an independent prognostic biomarker, associated with worse free-disease survival.
Databáze:	MEDLINE
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