Ranolazine Therapy in Cardiac Arrhythmias.

Autor: Pulford BR; Department of Medicine, University of Connecticut School of Medicine. bpulford@uchc.edu., Kluger J; Department of Cardiology, Hartford Hospital.
Jazyk: angličtina
Zdroj: Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2016 Sep; Vol. 39 (9), pp. 1006-15. Date of Electronic Publication: 2016 Jul 23.
DOI: 10.1111/pace.12905
Abstrakt: Ranolazine is an antianginal medication originally granted approval by the U.S. Food and Drug Administration for therapeutic use in 2006. Since its introduction into the U.S. market, there have been multiple trials and clinical case reports that demonstrate ranolazine may be effective in the prevention and treatment of both atrial and ventricular arrhythmias, including postoperative atrial fibrillation following coronary artery bypass graft (CABG) surgery. More recently, the combination of dronedarone with ranolazine has demonstrated in initial studies to have a synergistic effect in the reduction of burden of atrial fibrillation. This article will review the basic pharmacology of ranolazine, the studies demonstrating use of ranolazine in atrial and ventricular arrhythmias, the limitations to the use of ranolazine as antiarrhythmic therapy, and explore the synergistic effect with other agents in the suppression of arrhythmias.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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