| Autor: |
Pozzebon Venturini T; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Rossato L; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Chassot F; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Tairine Keller J; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Baldissera Piasentin F; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Morais Santurio J; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.; Postgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil., Hartz Alves S; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil. |
| Abstrakt: |
The genus Fusarium is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2). The interactions between antifungal and antimicrobial agents were evaluated by the microdilution checkerboard method. Pentamidine and polymyxin B showed MIC values ≥4 µg ml-1 against Fusarium spp. The highest rates of synergism were observed when amphotericin B or voriconazole was combined with tobramycin (80 % and 76 %, respectively), polymyxin B (76 % and 64 %) and pentamidine (72 % and 68 %). The most significant combinations deserve in vivo evaluations in order to verify their potential in the treatment of fusariosis. |
