Rapid malignant transformation of low-grade astrocytoma in a pregnant woman.

Autor: Hanada T; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. hanat@m2.kufm.kagoshima-u.ac.jp., Rahayu TU; Department of Neurosurgery, Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia., Yamahata H; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Hirano H; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Yoshioka T; Departement of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Arita K; Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2016 Oct; Vol. 42 (10), pp. 1385-1389. Date of Electronic Publication: 2016 Jun 30.
DOI: 10.1111/jog.13072
Abstrakt: We report rapid malignant transformation of diffuse astrocytoma to glioblastoma during pregnancy in a young woman. A 21-year-old woman was found to have a non-enhancing right frontal lesion, supposed to be a low-grade astrocytoma according to magnetic resonance imaging (MRI) studied for chronic headache. Due to the absence of clinical symptoms, the patient refused further investigations and delivered a baby and then became pregnant with a second baby. At first, she refused the biopsy because she was afraid, although the size of the lesion on MRI was increasing; however, due to repeated persuasion, she underwent a biopsy during the 4th month of her second gestation, with a result of diffuse astrocytoma (WHO grade II). At 1 month after the second delivery and 6 months after the biopsy, MRI revealed further enlargement of the tumor and a heterogeneous kenhancement effect. A gross tumor removal was carried out, and the tumor was histologically diagnosed as glioblastoma (WHO grade IV). This is the quickest ever malignant transformation of diffuse astrocytoma during pregnancy in the published reports.
(© 2016 Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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