Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances.

Autor:	Karimi M; Wellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts 02114, United States., Sahandi Zangabad P; Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS) , Tabriz, Iran.; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Ghasemi A; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Amiri M; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Bahrami M; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Malekzad H; Department of Chemistry, Kharazmi University of Tehran , Tehran, Iran., Ghahramanzadeh Asl H; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Mahdieh Z; Department of Biomedical and Pharmaceutical Sciences, Material Science and Engineering, University of Montana , Missoula, Montana 59812, United States., Bozorgomid M; Department of Applied Chemistry, Central Branch of Islamic Azad University of Tehran , Tehran, Iran., Ghasemi A; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Rahmani Taji Boyuk MR; Department of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran., Hamblin MR; Wellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.; Department of Dermatology, Harvard Medical School , Boston, Massachusetts 02115, United States.; Harvard-MIT Division of Health Sciences and Technology , Cambridge, Massachusetts 02139, United States.
Jazyk:	angličtina
Zdroj:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2016 Aug 24; Vol. 8 (33), pp. 21107-33. Date of Electronic Publication: 2016 Aug 11.
DOI:	10.1021/acsami.6b00371
Abstrakt:	Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications. Competing Interests: Notes The authors declare no competing financial interest.
Databáze:	MEDLINE
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