Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.

Autor: Wongrakpanich A; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand; Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand., Mudunkotuwa IA; Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States., Geary SM; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States., Morris AS; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States; Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States., Mapuskar KA; Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa city, IA 52242, United States., Spitz DR; Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa city, IA 52242, United States., Grassian VH; Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States; Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States., Salem AK; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States.
Jazyk: angličtina
Zdroj: Environmental science. Nano [Environ Sci Nano] 2016 Apr 01; Vol. 3 (2), pp. 365-374. Date of Electronic Publication: 2016 Feb 24.
DOI: 10.1039/C5EN00271K
Abstrakt: The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu 2+ and causing a differential impact on cytotoxicity.
Databáze: MEDLINE
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