Serum myeloperoxidase (MPO) activity, oxidative and antioxidative parameters in operating room personnel.

Autor:	Cegin MB; Department of Anaesthesiology and Reanimation, Turkey., Aslan M; Department of Internal Medicine, Yuzuncu Yil University, Medical Faculty, Van, Turkey., Goktas U; Department of Anaesthesiology and Reanimation, Turkey., Isik Y; Department of Anaesthesiology and Reanimation, Katip Celebi University, Medical Faculty, Izmir, Turkey., Soyoral L; Department of Anaesthesiology and Reanimation, Turkey., Aksoy N; Department of Clinical Biochemistry, Turkey., Taskin A; PhD Student, Harran University, Medical Faculty, Sanliurfa, Turkey., Kati I; Department of Anaesthesiology and Reanimation, Gazi University, Medical Faculty, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2016 Jun; Vol. 66 (6), pp. 666-70.
Abstrakt:	Objective: To investigate the effects of occupational exposure to anaesthetic gases on myeloperoxidase activity, oxidative and antioxidative parameters in operating room personnel. Methods: The cross-sectional study was conducted at Yuzuncu Yil University, Van, Turkey, in May 2011, and comprised equal number of operating room and non-operating room personnel. Serum myeloperoxidase activity, sulfhydryl group levels, lipid hydroperoxide levels and catalase activity were determined. SPSS 11 was used for data analysis. Results: There were 64 subjects; 32(50%) each in the two groups. Myeloperoxidase activity and lipid hydroperoxide levels were significantly higher in operating room personnel than in the non-operating room personnel (p<0.001; p<0.001), while catalase activity and sulfhydryl group levels were significantly lower (p<0.009; p<0.003). Catalase activity negatively correlated with lipid hydroperoxide levels in operating room personnel (r=-0.293; p=0.018). Myeloperoxidase activity negatively correlated with sulfhydryl group levels in operating room personnel (r=-0.267; p=0.031). Conclusions: Operating room personnel exhibited higher oxidative stress, which may be due to the oxidative effect of anaesthetic gases.
Databáze:	MEDLINE
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