Whole-genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011.

Autor: Byarugaba DK; College of Veterinary Medicine, Makerere University, Kampala, Uganda. dkb@covab.mak.ac.ug.; Makerere University Walter Reed Project, Kampala, Uganda. dkb@covab.mak.ac.ug., Erima B; Makerere University Walter Reed Project, Kampala, Uganda., Millard M; Makerere University Walter Reed Project, Kampala, Uganda., Kibuuka H; Makerere University Walter Reed Project, Kampala, Uganda., Lkwago L; Ministry of Health, Kampala, Uganda., Bwogi J; Uganda Virus Research Institute, Entebbe, Uganda., Mimbe D; Makerere University Walter Reed Project, Kampala, Uganda., Kiconco JB; Makerere University Walter Reed Project, Kampala, Uganda., Tugume T; Makerere University Walter Reed Project, Kampala, Uganda., Mworozi EA; College of Health Sciences, Makerere University, Kampala, Uganda., Turner J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Mckenzie PP; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Webby RR; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Webster RG; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Foret C; IHAP, INRA, ENVT, Université de Toulouse, Toulouse, France., Ducatez MF; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.; IHAP, INRA, ENVT, Université de Toulouse, Toulouse, France., Coldren R; U.S. Army Medical Research Directorate-Kenya, U.S. Embassy, Nairobi, Kenya., Wabwire-Mangen F; Makerere University Walter Reed Project, Kampala, Uganda., Krauss S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2016 Nov; Vol. 10 (6), pp. 486-492. Date of Electronic Publication: 2016 Jul 19.
DOI: 10.1111/irv.12401
Abstrakt: We report a whole-genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitutions V106I and N248D in the neuraminidase proteins with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 to 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%-1.3% and 0.1%-1.6% for HA and NA genes, respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains.
(© 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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