Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.

Autor: Jelenkovic A; Department of Social Research, University of Helsinki, Helsinki, Finland.; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain., Sund R; Department of Social Research, University of Helsinki, Helsinki, Finland., Hur YM; Department of Education, Mokpo National University, Jeonnam, South Korea., Yokoyama Y; Department of Public Health Nursing, Osaka City University, Osaka, Japan., Hjelmborg JV; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark., Möller S; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark., Honda C; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Ooki S; Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan., Aaltonen S; Department of Social Research, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Stazi MA; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy., Fagnani C; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy., D'Ippolito C; Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy., Freitas DL; Department of Physical Education and Sport, University of Madeira, Funchal, Portugal., Maia JA; CIFI2D, Faculty of Sport, Porto, University of Porto, Portugal., Ji F; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China., Ning F; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China., Pang Z; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China., Rebato E; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain., Busjahn A; HealthTwiSt GmbH, Berlin, Germany., Kandler C; Department of Psychology, Bielefeld University, Bielefeld, Germany., Saudino KJ; Boston University, Department of Psychological and Brain Sciencies, Boston, MA, USA., Jang KL; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada., Cozen W; Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, California, USA., Hwang AE; Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA., Mack TM; Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, California, USA., Gao W; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Yu C; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Corley RP; Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA., Huibregtse BM; Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA., Derom CA; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium., Vlietinck RF; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Heikkilä K; Department of Public Health, University of Helsinki, Helsinki, Finland., Wardle J; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK., Llewellyn CH; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK., Fisher A; Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK., McAdams TA; King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK., Eley TC; King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK., Gregory AM; Department of Psychology, Goldsmiths, University of London, London, UK., He M; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia., Ding X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China., Bjerregaard-Andersen M; Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.; Research Center for Vitamins and Vaccines, Statens Serum Institute, Copenhagen, Denmark.; Department of Endocrinology, Odense University Hospital, Odense, Denmark., Beck-Nielsen H; Department of Endocrinology, Odense University Hospital, Odense, Denmark., Sodemann M; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark., Tarnoki AD; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.; Hungarian Twin Registry, Budapest, Hungary., Tarnoki DL; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.; Hungarian Twin Registry, Budapest, Hungary., Knafo-Noam A; The Hebrew University of Jerusalem, Jerusalem, Israel., Mankuta D; Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel., Abramson L; The Hebrew University of Jerusalem, Jerusalem, Israel., Burt SA; Michigan State University, East Lansing, Michigan, USA., Klump KL; Michigan State University, East Lansing, Michigan, USA., Silberg JL; Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA., Eaves LJ; Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA., Maes HH; Department of Human and Molecular Genetics, Psychiatry &Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA., Krueger RF; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Pahlen S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Gatz M; Department of Psychology, University of Southern California, Los Angeles, CA, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Butler DA; Institute of Medicine, National Academy of Sciences, Washington, DC, USA., Bartels M; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands., van Beijsterveldt TC; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands., Craig JM; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia., Saffery R; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia., Dubois L; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada., Boivin M; École de psychologie, Université Laval, Québec, Canada.; Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian Federation., Brendgen M; Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada., Dionne G; École de psychologie, Université Laval, Québec, Canada., Vitaro F; École de psychoéducation, Université de Montréal, Montréal, Québec, Canada., Martin NG; Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Medland SE; Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Montgomery GW; Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Swan GE; Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Krasnow R; Center for Health Sciences, SRI International, Menlo Park, CA, USA., Tynelius P; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden., Lichtenstein P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Haworth CM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K., Plomin R; King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK., Bayasgalan G; Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia., Narandalai D; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia., Harden KP; Department of Psychology, University of Texas at Austin, Austin, TX, USA., Tucker-Drob EM; Department of Psychology, University of Texas at Austin, Austin, TX, USA., Spector T; Department of Twin Research and Genetic Epidemiology, King's College, London, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College, London, UK., Lachance G; Department of Twin Research and Genetic Epidemiology, King's College, London, UK., Baker LA; Department of Psychology, University of Southern California, Los Angeles, CA, USA., Tuvblad C; Department of Psychology, University of Southern California, Los Angeles, CA, USA.; School of Law, Psychology and Social Work, Örebro University, Sweden., Duncan GE; Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA., Buchwald D; Washington State Twin Registry, Washington State University, Seattle, WA, USA., Willemsen G; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands., Skytthe A; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark., Kyvik KO; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark., Christensen K; The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Öncel SY; Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey., Aliev F; Departments of Psychiatry, Psychology, and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA., Rasmussen F; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden., Goldberg JH; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Sørensen TI; Novo Nordisk Foundation Centre for Basic Metabolic Research (Section on Metabolic Genetics) and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands., Kaprio J; Department of Public Health, University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine FIMM, Helsinki, Finland., Silventoinen K; Department of Social Research, University of Helsinki, Helsinki, Finland.; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2016 Jun 23; Vol. 6, pp. 28496. Date of Electronic Publication: 2016 Jun 23.
DOI: 10.1038/srep28496
Abstrakt: Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
Databáze: MEDLINE