| Autor: |
Tsujita J, Doi K, Nakahara M, Nakahara T, Kaku Y, Nishio K, Kan N, Sato Y, Nagata S, Nakao A, Yoshida M, Uchi H, Furue M |
| Jazyk: |
angličtina |
| Zdroj: |
Fukuoka igaku zasshi = Hukuoka acta medica [Fukuoka Igaku Zasshi] 2016 Jan; Vol. 107 (1), pp. 12-7. |
| Abstrakt: |
The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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