Antimelanoma effect of Salmonella Typhimurium integration host factor mutant in murine model.

Autor:	Hirsch Werle C; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil., Damiani I; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil., Paier Milanez G; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil., Farias AS; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil., Cintra Gomes Marcondes MC; Department of Structural & Functional Biology, Institute of Biology, University of Campinas, Sao Paulo, Brazil., Fabricio Culler H; Laboratory of Genetics, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo, SP, Brazil., Palma Sircili M; Laboratory of Genetics, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo, SP, Brazil., Leite B; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil., Brocchi M; Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Future oncology (London, England) [Future Oncol] 2016 Oct; Vol. 12 (20), pp. 2367-78. Date of Electronic Publication: 2016 Jun 22.
DOI:	10.2217/fon-2015-0062
Abstrakt:	Aim: This study aimed to evaluate an attenuated Salmonella ihfA-null mutant strain as therapeutic agent to control tumor growth. Materials & Methods: After bacterial toxicity evaluation, C57BL/6JUnib mice were inoculated with B16F10 cells and treated with two Salmonella strains (LGBM 1.1 and LGBM 1.41). Results: LGBM 1.1 can reduce tumor mass, but it exerts some toxic effects. Although LGBM 1.41 is less toxic than LGBM 1.1, it does not reduce tumor mass significantly. Indeed, animals treated with LGBM 1.41 present only slightly initial delay in tumor progression and increased survival rate as compared with the control. Conclusion: The null-mutants of ihfA gene of Salmonella Typhimurium could be a promising candidate for melanoma treatment.
Databáze:	MEDLINE
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