Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease.

Autor: Mengel D; Department of Neurology, Philipps-University, Marburg, Germany., Dams J; Department of Neurology, Philipps-University, Marburg, Germany., Ziemek J; Department of Neurology, Philipps-University, Marburg, Germany., Becker J; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Balzer-Geldsetzer M; Department of Neurology, Philipps-University, Marburg, Germany., Hilker R; Department of Neurology, Goethe-University, Frankfurt/Main, Germany., Baudrexel S; Department of Neurology, Goethe-University, Frankfurt/Main, Germany., Kalbe E; Department of Medical Psychology & Center for Neuropsychological Diagnostics and Intervention (CeNDI), University Hospital Cologne, Cologne, Germany; Psychological Gerontology Institute of Gerontology, University of Vechta, Vechta, Germany., Schmidt N; Department of Neurology, Kiel University, Kiel, Germany., Witt K; Department of Neurology, Kiel University, Kiel, Germany., Liepelt-Scarfone I; Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, Tuebingen, Germany., Gräber S; Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, Tuebingen, Germany., Petrelli A; Psychological Gerontology Institute of Gerontology, University of Vechta, Vechta, Germany., Neuser P; Coordinating Centre for Clinical Trials, Philipps-University, Marburg, Germany., Schulte C; Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, Tuebingen, Germany., Linse K; Department of Neurology, Technical University Dresden, Germany., Storch A; Department of Neurology, University Medical Center Rostock, Germany., Wittchen HU; Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany., Riedel O; Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany; Leibniz Institute for Prevention Research and Epidemiology-BIPS GmbH, Bremen, Germany., Mollenhauer B; Paracelsus-Elena-Klinik, Kassel, Germany; Institute of Neuropathology, University Medical Center Goettingen, Goettingen, Germany., Ebentheuer J; Paracelsus-Elena-Klinik, Kassel, Germany., Trenkwalder C; Paracelsus-Elena-Klinik, Kassel, Germany., Klockgether T; Department of Neurology, University of Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany., Spottke A; Institute of Neuropathology, University Medical Center Goettingen, Goettingen, Germany; Department of Neurology, University of Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany., Wüllner U; Department of Neurology, University of Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany., Schulz JB; Department of Neurology, RWTH Aachen University, Aachen, Germany; JARA - Translational Brain Medicine, Jülich and Aachen, Germany., Reetz K; Department of Neurology, RWTH Aachen University, Aachen, Germany; JARA - Translational Brain Medicine, Jülich and Aachen, Germany., Heber IA; Department of Neurology, RWTH Aachen University, Aachen, Germany., Ramirez A; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany., Dodel R; Department of Neurology, Philipps-University, Marburg, Germany. Electronic address: dodel@med.uni-marburg.de.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2016 Aug; Vol. 29, pp. 112-6. Date of Electronic Publication: 2016 Apr 19.
DOI: 10.1016/j.parkreldis.2016.04.013
Abstrakt: Introduction: Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele ε4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains.
Methods: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance.
Results: The APOE-ε4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort.
Conclusion: Our data question the relevance of the APOE-ε4 allele as a predictor of cognitive impairment in PD.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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