Absence of calf muscle metabolism alterations in active cystic fibrosis adults with mild to moderate lung disease.

Autor: Decorte N; HP2 Laboratory, Grenoble-Alpes University, 38000 Grenoble, France; INSERM, U1042, 38000, Grenoble, France. Electronic address: ndecorte@chu-grenoble.fr., Gruet M; HP2 Laboratory, Grenoble-Alpes University, 38000 Grenoble, France; INSERM, U1042, 38000, Grenoble, France; LAMHESS EA 6312, Universities of Toulon and Nice Sophia-Antipolis, France., Camara B; Centre de ressources et de compétences de la mucoviscidose (CRCM), Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU Grenoble, France., Quetant S; Centre de ressources et de compétences de la mucoviscidose (CRCM), Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU Grenoble, France., Mely L; LAMHESS EA 6312, Universities of Toulon and Nice Sophia-Antipolis, France; Centre de ressources et de compétences de la mucoviscidose (CRCM), Hôpital Renée Sabran, Giens, France., Vallier JM; LAMHESS EA 6312, Universities of Toulon and Nice Sophia-Antipolis, France., Verges S; HP2 Laboratory, Grenoble-Alpes University, 38000 Grenoble, France; INSERM, U1042, 38000, Grenoble, France., Wuyam B; HP2 Laboratory, Grenoble-Alpes University, 38000 Grenoble, France; INSERM, U1042, 38000, Grenoble, France.
Jazyk: angličtina
Zdroj: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2017 Jan; Vol. 16 (1), pp. 98-106. Date of Electronic Publication: 2016 Jun 15.
DOI: 10.1016/j.jcf.2016.05.010
Abstrakt: Background: Specific alterations in skeletal muscle related to genetic defects may be present in adults with cystic fibrosis (CF). Limb muscle dysfunction may contribute to physical impairment in CF.
Aims and Objectives: We hypothesized that adults with CF would have altered calf muscle metabolism during exercise.
Methods: Fifteen adults with CF and fifteen healthy controls matched for age, gender and physical activity performed a maximal cycling test and an evaluation of calf muscle energetics by 31 P magnetic resonance spectroscopy before, during and after plantar flexions to exhaustion.
Results: Maximal cycling test revealed lower exercise capacities in CF (VO 2peak 2.44±0.11 vs. 3.44±0.23L·Min -1 , P=0.03). At rest, calf muscle phosphorus metabolites and pHi were similar in CF and controls (P>0.05). Maximal power output during plantar flexions was significantly lower in CF compared to controls (7.8±1.2 vs. 6.6±2.4W; P=0.013). At exhaustion, PCr concentration was similarly reduced in both groups (CF -33±7%, controls -34±6%, P=0.44), while PCr degradation at identical absolute workload was greater in CF patients (P=0.04). These differences disappeared when power output was normalized for differences in calf size (maximal power output: 0.10±0.02 vs. 0.10±0.03W/cm 2 ; P=0.87). Pi/PCr ratio and pHi during exercise as well as PCr recovery after exercise were similar between groups.
Conclusion: Similar metabolic calf muscle responses during exercise and recovery were found in CF adults and controls. Overall, muscle anabolism rather than specific metabolic dysfunction may be critical regarding muscle function in CF.
(Copyright © 2016. Published by Elsevier B.V.)
Databáze: MEDLINE
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