Melanoma metastases caught in the AKT.
| Autor: | Kircher DA; Department of Oncological Sciences, University of Utah Health Sciences Center , Salt Lake City, Utah, USA., Arave RA; Department of Chemistry, University of Utah Health Sciences Center , Salt Lake City, Utah, USA., Cho JH; Department of Oncological Sciences, University of Utah Health Sciences Center , Salt Lake City, Utah, USA., Holmen SL; Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular & cellular oncology [Mol Cell Oncol] 2016 Feb 18; Vol. 3 (2), pp. e1128516. Date of Electronic Publication: 2016 Feb 18 (Print Publication: 2016). |
| DOI: | 10.1080/23723556.2015.1128516 |
| Abstrakt: | Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context. |
| Databáze: | MEDLINE |
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