| Autor: |
Katz IS; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil. ianasuly@gmail.com., Fuoco NL; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil., Chaves LB; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil., Rodrigues AC; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil., Ribeiro OG; Laboratório de Imunogenética, Instituto Butantan of São Paulo, São Paulo, SP, Brazil., Scheffer KC; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil., Asano KM; Laboratório de Diagnóstico da Raiva, Instituto Pasteur of São Paulo, São Paulo, SP, Brazil. |
| Abstrakt: |
Here, we compared the growth kinetics, cell-to-cell spread, and virus internalization kinetics in N2a cells of RABV variants isolated from vampire bats (V-3), domestic dogs (V-2) and marmosets (V-M) as well as the clinical symptoms and mortality caused by these variants. The replication rate of V-3 was significantly higher than those of V-2 and V-M. However, the uptake and spread of these RABV variants into N2a cells were inversely proportional. Nevertheless, V-3 had longer incubation and evolution periods. Our results provide evidence that the clinical manifestations of infection with bat RABV variant occur at a later time when compared to what was observed with canine and marmoset rabies virus variants. |
Full text from SpringerLink