Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam.

Autor: Yoshihara K; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.; Leading Program, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, 852-8523, Japan., Le MN; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam., Okamoto M; Department of Virology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Wadagni AC; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan., Nguyen HA; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam., Toizumi M; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan., Pham E; Khanh Hoa General Hospital, Nha Trang, Vietnam., Suzuki M; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan., Nguyen AT; Khanh Hoa General Hospital, Nha Trang, Vietnam., Oshitani H; Department of Virology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Ariyoshi K; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan., Moriuchi H; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.; Department of Pediatrics, Nagasaki University Hospital, Nagasaki, 852-8102, Japan., Hashizume M; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan., Dang DA; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam., Yoshida LM; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2016 Jun 16; Vol. 6, pp. 27856. Date of Electronic Publication: 2016 Jun 16.
DOI: 10.1038/srep27856
Abstrakt: Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37-3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01-3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.
Databáze: MEDLINE
Externí odkaz: