Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013.

Autor:	Bowen MD; Centers for Disease Control and Prevention, Atlanta, Georgia., Mijatovic-Rustempasic S; Centers for Disease Control and Prevention, Atlanta, Georgia., Esona MD; Centers for Disease Control and Prevention, Atlanta, Georgia., Teel EN; Centers for Disease Control and Prevention, Atlanta, Georgia., Gautam R; Centers for Disease Control and Prevention, Atlanta, Georgia., Sturgeon M; Centers for Disease Control and Prevention, Atlanta, Georgia., Azimi PH; UCSF Benioff Children's Hospital Oakland., Baker CJ; Texas Children's Hospital Baylor College of Medicine, Houston, Texas., Bernstein DI; Cincinnati Children's Hospital Medical Center, Ohio., Boom JA; Texas Children's Hospital Baylor College of Medicine, Houston, Texas., Chappell J; Vanderbilt University Medical Center, Nashville, Tennessee., Donauer S; Cincinnati Children's Hospital Medical Center, Ohio., Edwards KM; Vanderbilt University Medical Center, Nashville, Tennessee., Englund JA; Seattle Children's Hospital, Washington., Halasa NB; Vanderbilt University Medical Center, Nashville, Tennessee., Harrison CJ; Children's Mercy Hospitals and Clinics, Kansas City, Missouri., Johnston SH; UCSF Benioff Children's Hospital Oakland., Klein EJ; Seattle Children's Hospital, Washington., McNeal MM; Cincinnati Children's Hospital Medical Center, Ohio., Moffatt ME; Children's Mercy Hospitals and Clinics, Kansas City, Missouri., Rench MA; Texas Children's Hospital Baylor College of Medicine, Houston, Texas., Sahni LC; Texas Children's Hospital., Selvarangan R; Children's Mercy Hospitals and Clinics, Kansas City, Missouri., Staat MA; Cincinnati Children's Hospital Medical Center, Ohio., Szilagyi PG; University of California-Los Angeles., Weinberg GA; University of Rochester School of Medicine and Dentistry, New York., Wikswo ME; Centers for Disease Control and Prevention, Atlanta, Georgia., Parashar UD; Centers for Disease Control and Prevention, Atlanta, Georgia., Payne DC; Centers for Disease Control and Prevention, Atlanta, Georgia.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2016 Sep 01; Vol. 214 (5), pp. 732-8. Date of Electronic Publication: 2016 Jun 14.
DOI:	10.1093/infdis/jiw233
Abstrakt:	Background: Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006. Methods: Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping. Results: In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype. Conclusions: Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure. Competing Interests: Potential conflicts of interest. D. I. B. has a patent and received royalties for what is now Rotarix vaccine. M. M. M. has laboratory service agreements with GlaxoSmithKline and Merck. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu