The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury.

Autor: Corona-Ramos JN; Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México., De la O-Arciniega M; Área Académica de Farmacia del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México., Déciga-Campos M; Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina del IPN, C.P. 11340, México D.F., México., Medina-López JR; Depto. de Sistemas Biológicos UAM-Xochimilco, C.P. 04960, México, D.F., México., Domínguez-Ramírez AM; Depto. de Sistemas Biológicos UAM-Xochimilco, C.P. 04960, México, D.F., México., Jaramillo-Morales OA; Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México., Espinosa-Juárez JV; Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México., López-Muñoz FJ; Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México.
Jazyk: angličtina
Zdroj: Drug development research [Drug Dev Res] 2016 Aug; Vol. 77 (5), pp. 217-26. Date of Electronic Publication: 2016 Jun 14.
DOI: 10.1002/ddr.21313
Abstrakt: Preclinical Research The current work evaluates the interaction between two commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests. Tra and Gbp produced dose-dependent antihyperalgesic and anti-allodynic effects. Dose-response studies of combinations of Tra and Gbp in combination showed the DRC was leftward-shifted compared to the DRCs for each compound alone. One combination demonstrated both antihyperalgesic and anti-allodynic effects greater than those observed after individual administration. The remaining combinations demonstrated an additive effect. The Tra+Gbp combination demonstrated a potentiative effect with smaller doses of Tra. Additionally, it was determined lethal dose 50 (LD50 ) of Tra alone and tramadol + Gbp 10 using mice to 48 h post administration. The DRC (death) were similar for Tra alone and in Tra in combination, despite the improved effectiveness of Tra in the presence of GBP, 10 mg/kg. A combination of these drugs could be effective in neuropathic pain therapy because they can produce potentiative (at a low dose) or additive effects. Drug Dev Res 77 : 217-226, 2016.   © 2016 Wiley Periodicals, Inc.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: