Prognostic value of PCT, copeptin, MR-proADM, MR-proANP and CT-proET-1 for severe acute dyspnea in the emergency department: the BIODINER study.

Autor: Hausfater P; a Sorbonne Universités UPMC-Univ Paris06, UMRS INSERM 1166, IHU ICAN , GRC BIOSFAST, Paris , France.; b Emergency Department, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux De Paris (APHP) , Paris , France., Claessens YE; c Centre Hospitalier Princesse Grace, Monaco., Martinage A; d SAMU 44 CHU Hôtel-Dieu , Nantes Cedex 01 , France., Joly LM; e Emergency Department, CHU De Rouen, Hôpital Charles Nicolle Et Faculté De Médecine De Rouen , Rouen Cedex , France., Lardeur JY; f Emergency Department, CHRU Poitiers La Miletrie , Poitiers , France., Der Sahakian G; g Emergency Department , Hôpital Hôtel-Dieu, AP-HP , Paris Cedex 4 , France., Lemanski C; h Emergency Department , CHR Lille-Hôpital B , Lille Cedex., Ray P; a Sorbonne Universités UPMC-Univ Paris06, UMRS INSERM 1166, IHU ICAN , GRC BIOSFAST, Paris , France.; i Emergency Department, Hôpital Tenon, AP-HP , Paris Cedex 20 , France., Freund Y; a Sorbonne Universités UPMC-Univ Paris06, UMRS INSERM 1166, IHU ICAN , GRC BIOSFAST, Paris , France.; b Emergency Department, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux De Paris (APHP) , Paris , France., Riou B; a Sorbonne Universités UPMC-Univ Paris06, UMRS INSERM 1166, IHU ICAN , GRC BIOSFAST, Paris , France.; b Emergency Department, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux De Paris (APHP) , Paris , France.
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2017 Feb; Vol. 22 (1), pp. 28-34. Date of Electronic Publication: 2016 Jun 29.
DOI: 10.1080/1354750X.2016.1201541
Abstrakt: Context: Acute dyspnea is a frequent complaint in patients attending the emergency department (ED).
Objective: To evaluate the accuracy of PCT, MR-proANP, MR-proADM, copeptin and CT-proET1 for the risk-stratification of severe acute dyspnea patients presenting to the ED.
Methods: Multicenter prospective study in adult patients with a chief complaint of acute dyspnea. Pro-hormone type biomarkers concentrations were measured on arrival. Combined primary endpoint was a poor outcome.
Results: Three hundred and ninety-four patients were included, 137 (35%) met the primary endpoint. MR-proADM was the only biomarker associated with the primary endpoint (odds ratio 1.43 [95%CI: 1.13-1.82], p = 0.003) as were the presence of paradoxical abdominal breathing (odds ratio 2.48 [95%CI: 1.31-4.68]) or cyanosis (odds ratio 3.18 [1.46-6.89]) Conclusions: In patients with severe acute dyspnea in the ED, pro-hormone type biomarkers measurements have a low added value to clinical signs for the prediction of poor outcome.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje