A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial.

Autor: Willeboordse M; Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands., van de Kant KDG; Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands., Tan FE; Department of Methodology and Statistics, CAPHRI, MUMC, Maastricht, the Netherlands., Mulkens S; Department of Clinical Psychological Science, School for Experimental Psychopathology (EPP), Maastricht University, Faculty of Psychology and Neuroscience, Maastricht, the Netherlands., Schellings J; Department of Physiotherapy, MUMC, Maastricht, the Netherlands., Crijns Y; Department of Physiotherapy, MUMC, Maastricht, the Netherlands., Ploeg Lv; Department of Dietetics, MUMC, Maastricht, the Netherlands., van Schayck CP; Department of Family Medicine, CAPHRI, MUMC, Maastricht, the Netherlands., Dompeling E; Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2016 Jun 13; Vol. 11 (6), pp. e0157158. Date of Electronic Publication: 2016 Jun 13 (Print Publication: 2016).
DOI: 10.1371/journal.pone.0157158
Abstrakt: Background: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.
Objective: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.
Methods: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.
Results: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).
Conclusions & Clinical Relevance: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.
Trial Registration: ClinicalTrials.gov NCT00998413.
Databáze: MEDLINE
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