Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology.

Autor: Sanders JL; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania., Singh J; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Minster RL; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Walston JD; Department of Medicine, Johns Hopkins University, Baltimore, Maryland., Matteini AM; Department of Medicine, Johns Hopkins University, Baltimore, Maryland., Christensen K; Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark., Mayeux R; Department of Neurology, Columbia University, New York, New York., Borecki IB; Division of Statistical Genetics, Washington University in St. Louis, St. Louis, Missouri., Perls T; Department of Medicine, Boston University, Boston, Massachusetts., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2016 Aug; Vol. 64 (8), pp. 1679-83. Date of Electronic Publication: 2016 Jun 13.
DOI: 10.1111/jgs.14190
Abstrakt: Objectives: To investigate the association between mortality and heritability of a rescaled Fried frailty index, the Scale of Aging Vigor in Epidemiology (SAVE), to determine its value for genetic analyses.
Design: Longitudinal, community-based cohort study.
Setting: The Long Life Family Study (LLFS) in the United States and Denmark.
Participants: Long-lived individuals (N = 4,875, including 4,075 genetically related individuals) and their families (N = 551).
Measurements: The SAVE was administered to 3,599 participants and included weight change, weakness (grip strength), fatigue (questionnaire), physical activity (days walked in prior 2 weeks), and slowness (gait speed); each component was scored 0, 1, or 2 using approximate tertiles, and summed (range 0 (vigorous) to 10 (frail)). Heritability was determined using a variance component-based family analysis using a polygenic model. Association with mortality in the proband generation (N = 1,421) was calculated using Cox proportional hazards mixed-effect models.
Results: Heritability of the SAVE was 0.23 (P < .001) overall (n = 3,599), 0.31 (P < .001) in probands (n = 1,479), and 0.26 (P < .001) in offspring (n = 2,120). In adjusted models, higher SAVE scores were associated with higher mortality (score 5-6: hazard ratio (HR) = 2.83, 95% confidence interval (CI) = 1.46-5.51; score 7-10: HR = 3.40, 95% CI = 1.72-6.71) than lower scores (0-2).
Conclusion: The SAVE was associated with mortality and was moderately heritable in the LLFS, suggesting a genetic component to age-related vigor and frailty and supporting its use for further genetic analyses.
(© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.)
Databáze: MEDLINE
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