Effect of cigarette smoke on counts of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa in young patients with perennial allergic rhinitis.

Autor:	Montaño-Velázquez BB; Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico., Flores-Rojas EB; Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico., García-Vázquez FJ; Instituto Nacional de Pediatría, Molecular Pathology Laboratory, Department of Pathology Anatomy, Mexico City, Mexico., Jurado-Hernandez S; Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico., Venancio Hernández MA; Instituto Mexicano del Seguro Social, CMN La Raza, Hospital de Especialidades, Service of Immunology and Allergy, Mexico City, Mexico., Alanis Flores AK; Instituto Mexicano del Seguro Social, CMN La Raza, Hospital de Especialidades, Service of Immunology and Allergy, Mexico City, Mexico., Jáuregui-Renaud K; Instituto Mexicano del Seguro Social, Centro Médico Nacional sXXI, P.B. Edificio C Salud en el Trabajo, Medical Research Unit in Otoneurology, Mexico City, Mexico. Electronic address: kathrine.jauregui@imss.gob.mx.
Jazyk:	angličtina
Zdroj:	Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2017 Jul - Aug; Vol. 83 (4), pp. 420-425. Date of Electronic Publication: 2016 May 19.
DOI:	10.1016/j.bjorl.2016.04.011
Abstrakt:	Introduction: In teenagers with perennial allergic rhinitis, exposure to tobacco cigarette smoke increases the count of eosinophils in the nasal mucosa; the recruitment of eosinophils arises from the combined action of a number of cellular and molecular signals, including eotaxin. Objective: To assess the effect of exposure to tobacco cigarette smoke on the count of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa of children and teenagers with perennial allergic rhinitis. Methods: In a cross-sectional study, forty-four patients were evaluated (aged 7-19 years old): 22 with and 22 with no exposure to tobacco cigarette smoke. After replying to 2 validated questionnaires, on Asthma and Allergies in Childhood and on the severity of nasal symptoms, nasal mucosal samples were obtained by scraping the middle one-third of the inferior turbinates. Then counts of immunoreactive cells to eotaxin-1 and eosinophils were assessed by immunohistochemistry. Results: Patients with exposure to tobacco cigarette smoke showed higher cell counts of both eotaxin-1 and eosinophils than patients with no exposure to the smoke, with no correlation between the two variables. However, both counts, of eotaxin-1 and eosinophils, were related to the cotinine/creatinine ratio. Conclusions: Exposure to tobacco cigarette smoke can increase eotaxin-1 and the count of eosinophils in the nasal mucosa of young patients with perennial allergic rhinitis. (Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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