Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition.

Autor:	Petrella LI; Institute of Nuclear Science Applied to Health, University of Coimbra, Coimbra, Portugal.; Center for Neuroscience and Cell Biology - Institute of Biomedical Imaging and Life Science (CNC.IBILI), University of Coimbra, Coimbra, Portugal., Cai Y; Department of Neurobiology, University of California, Los Angeles, CA, USA.; Department of Psychology, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.; Integrative Center for Learning and Memory, University of California, Los Angeles, CA, USA.; Brain Research Institute, University of California, Los Angeles, CA, USA., Sereno JV; Institute of Nuclear Science Applied to Health, University of Coimbra, Coimbra, Portugal.; Center for Neuroscience and Cell Biology - Institute of Biomedical Imaging and Life Science (CNC.IBILI), University of Coimbra, Coimbra, Portugal., Gonçalves SI; Institute of Nuclear Science Applied to Health, University of Coimbra, Coimbra, Portugal.; Center for Neuroscience and Cell Biology - Institute of Biomedical Imaging and Life Science (CNC.IBILI), University of Coimbra, Coimbra, Portugal., Silva AJ; Department of Neurobiology, University of California, Los Angeles, CA, USA.; Department of Psychology, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.; Integrative Center for Learning and Memory, University of California, Los Angeles, CA, USA.; Brain Research Institute, University of California, Los Angeles, CA, USA., Castelo-Branco M; Institute of Nuclear Science Applied to Health, University of Coimbra, Coimbra, Portugal. mcbranco@fmed.uc.pt.; Center for Neuroscience and Cell Biology - Institute of Biomedical Imaging and Life Science (CNC.IBILI), University of Coimbra, Coimbra, Portugal. mcbranco@fmed.uc.pt.
Jazyk:	angličtina
Zdroj:	Genes, brain, and behavior [Genes Brain Behav] 2016 Sep; Vol. 15 (7), pp. 637-46. Date of Electronic Publication: 2016 Jul 05.
DOI:	10.1111/gbb.12305
Abstrakt:	Neurofibromatosis type-1 (NF1) is a common neurogenetic disorder and an important cause of intellectual disability. Brain-behaviour associations can be examined in vivo using morphometric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) to study brain structure. Here, we studied structural and behavioural phenotypes in heterozygous Nf1 mice (Nf1(+/-) ) using T2-weighted imaging MRI and DTI, with a focus on social recognition deficits. We found that Nf1(+/-) mice have larger volumes than wild-type (WT) mice in regions of interest involved in social cognition, the prefrontal cortex (PFC) and the caudate-putamen (CPu). Higher diffusivity was found across a distributed network of cortical and subcortical brain regions, within and beyond these regions. Significant differences were observed for the social recognition test. Most importantly, significant structure-function correlations were identified concerning social recognition performance and PFC volumes in Nf1(+/-) mice. Analyses of spatial learning corroborated the previously known deficits in the mutant mice, as corroborated by platform crossings, training quadrant time and average proximity measures. Moreover, linear discriminant analysis of spatial performance identified 2 separate sub-groups in Nf1(+/-) mice. A significant correlation between quadrant time and CPu volumes was found specifically for the sub-group of Nf1(+/-) mice with lower spatial learning performance, suggesting additional evidence for reorganization of this region. We found strong evidence that social and spatial cognition deficits can be associated with PFC/CPu structural changes and reorganization in NF1. (© 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF