| Autor: |
Perera-Bobusch C; Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195 Berlin, Germany. nora.kulak@fu-berlin.de., Hormann J, Weise C, Wedepohl S, Dernedde J, Kulak N |
| Jazyk: |
angličtina |
| Zdroj: |
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2016 Jul 14; Vol. 45 (26), pp. 10500-4. Date of Electronic Publication: 2016 Jun 09. |
| DOI: |
10.1039/c6dt00681g |
| Abstrakt: |
A simple approach towards efficient artificial proteases based on the cyclen ligand is presented. We thus achieved an increase of the proteolytic activity of two orders of magnitude when compared to the unsubstituted cyclen complex. Amphiphilic Cu(ii) and Co(iii) complexes cut BSA and myoglobin as model substrates at μM concentrations. MALDI-ToF MS is used to identify the cleavage fragments. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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