Glutathione Transferase as a Potential Marker for Gut Epithelial Injury versus the Protective Role of Breast Milk sIgA in Infants with Rota Virus Gastroenteritis.

Autor:	Sherif LS; National Research Centre, Department of Child Health, Giza, Egypt., Raouf RK; Institute of Postgraduate Childhood Studies - Department of Medical Studies, Cairo, Egypt., Sayede RM; Kasralainy Cairo University - Pediatric, Cairo, Egypt., Wakkadd AS; National Research Centre, Medical Physiology, Cairo, Egypt., Shoaib AR; National Research Centre, Department of Virology, Giza, Egypt., Ali HM; National Research Centre, Department of Cell Biology, Giza, Egypt., Refay AS; National Research Centre, Department of Child Health, Giza, Egypt.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2015 Dec 15; Vol. 3 (4), pp. 676-80. Date of Electronic Publication: 2015 Nov 26.
DOI:	10.3889/oamjms.2015.125
Abstrakt:	Background: Secretory immunoglobulin A (SIgA) plays an important protective role in the recognition and clearance of enteric pathogens. Aim: This study was designed to assess if mucosal integrity "measured by secretory IgA (SIgA)" is a protective factor from more epithelial alteration "measured by glutathione transferase" in infants with Rota gastroenteritis and its relation to infants' feeding pattern. Patients and Methods: This study was conducted on 79 infants aged 6 months and less from those diagnosed as having gastroenteritis and admitted to Gastroenteritis Department in Abo El Rish Pediatric Hospital, Cairo University. Plasma glutathione s-transferases and Stool SIgA were measured using ELISA technique. Rota virus detection was done by Reverse transcriptase PCR. Results: SIgA was found to be significantly positive in exclusive breast fed infants, Glutathione transferase was significantly more frequently positive in Rota positive cases than Rota negative cases by Reverse transcriptase PCR. A significant negative correlation between Glutathione transferase and Secretory IgA was found, (p < 0.05). Conclusion: Breast feeding should be encouraged and highly recommended in the first two years of life as it provides Secretory IgA to breast fed infants who in turn protect them against epithelial damage caused by Rota viral gastroenteritis.
Databáze:	MEDLINE
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