Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature.
| Autor: | den Hertog AL; Royal Tropical Institute (KIT), KIT Biomedical Research, Amsterdam, The Netherlands adenhertog@gmail.com r.anthony@planet.nl., Menting S; Royal Tropical Institute (KIT), KIT Biomedical Research, Amsterdam, The Netherlands., Pfeltz R; Becton Dickinson Diagnostic Systems, Sparks, Maryland, USA., Warns M; Becton Dickinson Diagnostic Systems, Sparks, Maryland, USA., Siddiqi SH; Becton Dickinson Diagnostic Systems, Sparks, Maryland, USA., Anthony RM; Royal Tropical Institute (KIT), KIT Biomedical Research, Amsterdam, The Netherlands adenhertog@gmail.com r.anthony@planet.nl. |
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| Jazyk: | angličtina |
| Zdroj: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Jul 22; Vol. 60 (8), pp. 4956-60. Date of Electronic Publication: 2016 Jul 22 (Print Publication: 2016). |
| DOI: | 10.1128/AAC.00654-16 |
| Abstrakt: | For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible to pyrazinamide for in vitro testing. Here, we show that at the standard breakpoint concentration and reduced culture temperatures, pyrazinamide (PZA) is active against tuberculosis (TB) at neutral pH. This finding should help unravel the mechanism of action of PZA and allow drug susceptibility testing (DST) methods to be optimized. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.) |
| Databáze: | MEDLINE |
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